Lifetime bipolar disorder comorbidity and related clinical characteristics in patients with primary obsessive compulsive disorder: a report from the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS).
Journal: CNS spectrums
Volume: 25
Issue: 3
Year of Publication: 2021
Affiliated Institutions:
Department of Mental Health, Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan, Milan, Italy.
Mental Health Unit, Hertfordshire Partnership Foundation Trust, QueenElizabeth II Hospital, Welwyn Garden City, UK.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, MacAnxiety Research Center, Hamilton, Canada.
Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine and Montefiore Medical Center, New York, NY, USA.
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry, Bellvitge University Hospital-IDIBELL, University of Barcelona, Cibersam, Barcelona, Spain.
Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Laboratorio de Genómica de Enfermedades Psiquiátricas y Neurodegenerativas, Instituto Nacional de Medicina Genómica, Ciudad de México, Mexico.
Department of Clinical Research, Grupo Médico Carracci, Ciudad de México, México.
Department of Psychiatry, University of Florence, and Institute of Neurosciences, Florence, Italy.
MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Stellenbosch, South Africa.
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Psichiatria, Università di Pisa, Pisa, Italy.
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry Sveti Naum, Sofia, Bulgaria.
Department of Psychiatry, Sisli Eftal Teaching and Research Hospital, Istanbul, Turkey.
Department of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Abstract summary
Bipolar disorder (BD) and obsessive compulsive disorder (OCD) are prevalent, comorbid, and disabling conditions, often characterized by early onset and chronic course. When comorbid, OCD and BD can determine a more pernicious course of illness, posing therapeutic challenges for clinicians. Available reports on prevalence and clinical characteristics of comorbidity between BD and OCD showed mixed results, likely depending on the primary diagnosis of analyzed samples.We assessed prevalence and clinical characteristics of BD comorbidity in a large international sample of patients with primary OCD (n = 401), through the International College of Obsessive-Compulsive Spectrum Disorders (ICOCS) snapshot database, by comparing OCD subjects with vs without BD comorbidity.Among primary OCD patients, 6.2% showed comorbidity with BD. OCD patients with vs without BD comorbidity more frequently had a previous hospitalization (p < 0.001) and current augmentation therapies (p < 0.001). They also showed greater severity of OCD (p < 0.001), as measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).These findings from a large international sample indicate that approximately 1 out of 16 patients with primary OCD may additionally have BD comorbidity along with other specific clinical characteristics, including more frequent previous hospitalizations, more complex therapeutic regimens, and a greater severity of OCD. Prospective international studies are needed to confirm our findings.
Authors & Co-authors:
Dell'Osso Bernardo B
Vismara Matteo M
Benatti Beatrice B
Cirnigliaro Giovanna G
Grancini Benedetta B
Fineberg Naomi A NA
Van Ameringen Michael M
Hollander Eric E
Stein Dan J DJ
Menchon Josè M JM
Rodriguez Carolyn I CI
Nicolini Humberto H
Lanzagorta Nuria N
Pallanti Stefano S
Grassi Giacomo G
Lochner Christine C
Marazziti Donatella D
Hranov Georgi G
Karamustafalioglu Oguz O
Hranov Luchezar L
Zohar Joseph J
Study Outcome
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