An evolutionary perspective on complex neuropsychiatric disease.
Journal: Neuron
Volume: 112
Issue: 1
Year of Publication: 2024
Affiliated Institutions:
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA , USA.
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX , USA.
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY , USA.
Department of Genetics, University of North Carolina, Chapel Hill, NC , USA.
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA , USA.
Department of Medicine and Department of Genome Sciences, University of Washington, Seattle, WA , USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY , USA.
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru , India.
Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei , Taiwan.
Faculty of Sciences, University of the Andes, Bogotá, Colombia.
Department of Genetics and Evolutionary Biology, University of São Paulo, São Paulo, Brazil.
SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA , USA; Department of Medicine and Department of Genome Sciences, University of Washington, Seattle, WA , USA.
Department of Epidemiology, Mailman School of Public Health, and New York State Psychiatric Institute, Columbia University, New York, NY , USA.
Broad Institute of MIT and Harvard, Cambridge, MA , USA; Division of Genetics and Genomics and Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA , USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA , USA.
Department of Medicine and Department of Genome Sciences, University of Washington, Seattle, WA , USA. Electronic address: mcking@uw.edu.
Abstract summary
The forces of evolution-mutation, selection, migration, and genetic drift-shape the genetic architecture of human traits, including the genetic architecture of complex neuropsychiatric illnesses. Studying these illnesses in populations that are diverse in genetic ancestry, historical demography, and cultural history can reveal how evolutionary forces have guided adaptation over time and place. A fundamental truth of shared human biology is that an allele responsible for a disease in anyone, anywhere, reveals a gene critical to the normal biology underlying that condition in everyone, everywhere. Understanding the genetic causes of neuropsychiatric disease in the widest possible range of human populations thus yields the greatest possible range of insight into genes critical to human brain development. In this perspective, we explore some of the relationships between genes, adaptation, and history that can be illuminated by an evolutionary perspective on studies of complex neuropsychiatric disease in diverse populations.
Authors & Co-authors:
McClellan Jon M JM
Zoghbi Anthony W AW
Buxbaum Joseph D JD
Cappi Carolina C
Crowley James J JJ
Flint Jonathan J
Grice Dorothy E DE
Gulsuner Suleyman S
Iyegbe Conrad C
Jain Sanjeev S
Kuo Po-Hsiu PH
Lattig Maria Claudia MC
Passos-Bueno Maria Rita MR
Purushottam Meera M
Stein Dan J DJ
Sunshine Anna B AB
Susser Ezra S ES
Walsh Christopher A CA
Wootton Olivia O
King Mary-Claire MC
Study Outcome
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