Modeling psychological function in patients with schizophrenia with the PANSS: an international multi-center study.
Journal: CNS spectrums
Volume: 26
Issue: 3
Year of Publication: 2022
Affiliated Institutions:
rd Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Medical and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Linköping, Sweden.
University Psychiatric Center, Katholieke Universiteit Leuven, Kortenberg, Belgium.
University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry "Sveti Naum", Sofia, Bulgaria.
Department of Psychiatry, Queen's University, Providence Care Hospital, Kingston, Ontario, Canada.
National Institute of Mental Health, Klecany, Czech Republic.
Department of Psychiatry, University of Turku, Turku, Finland.
Department of Psychiatry, Sainte Marguerite University Hospital, Marseille, France.
Department of Psychiatry, Ruhr University Bochum, Bochum, Germany.
nd Department of Psychiatry, National and Kapodistrian University of Athens, Athens, Greece.
Department of Psychiatry, National and Kapodistrian University of Athens School of Medicine, Eginition Hospital, Athens, Greece.
Nyírő Gyula Hospital, Budapest, Hungary.
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
Western University, London, Ontario, Canada.
Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Department of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Department of Psychiatry and Narcology, Riga Stradins University, Riga, Latvia.
Department of Clinic of Psychiatric, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Clinical Department of Psychiatry, Clinical Centre of Montenegro, Podgorica, Montenegro.
Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
Department of Psychiatry and Mental Health, Santa Maria University Hospital, Lisbon, Portugal.
University of Medicine and Pharmacy of Târgu Mures, Târgu Mures, Romania.
Department of Psychiatry, Samara Psychiatric Hospital, Inpatient Unit, Samara State Medical University, Samara, Russia.
Institute of Mental Health, Belgrade, Serbia.
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Department of Psychiatry, University of Oviedo and Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Oviedo, Spain.
Psychiatry Department, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Department of Psychiatry, Lokmanya Tilak Municipal Medical College, Mumbai, India.
University of Medicine and Pharmacy of Timisoara, Timisoara, Romania.
Institute of Mental Health, School of Medicine, University of Belgrade, Belgrade, Serbia.
Department of Psychiatry, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
st Department of Psychiatry, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece.
MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
IMPACT Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, Australia.
Department of Psychiatry, University of Florida, Gainesville, Florida, USA.
Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
Abstract summary
The aim of the current study was to explore the changing interrelationships among clinical variables through the stages of schizophrenia in order to assemble a comprehensive and meaningful disease model.Twenty-nine centers from 25 countries participated and included 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Multiple linear regression analysis and visual inspection of plots were performed.The results suggest that with progression stages, there are changing correlations among Positive and Negative Syndrome Scale factors at each stage and each factor correlates with all the others in that particular stage, in which this factor is dominant. This internal structure further supports the validity of an already proposed four stages model, with positive symptoms dominating the first stage, excitement/hostility the second, depression the third, and neurocognitive decline the last stage.The current study investigated the mental organization and functioning in patients with schizophrenia in relation to different stages of illness progression. It revealed two distinct "cores" of schizophrenia, the "Positive" and the "Negative," while neurocognitive decline escalates during the later stages. Future research should focus on the therapeutic implications of such a model. Stopping the progress of the illness could demand to stop the succession of stages. This could be achieved not only by both halting the triggering effect of positive and negative symptoms, but also by stopping the sensitization effect on the neural pathways responsible for the development of hostility, excitement, anxiety, and depression as well as the deleterious effect on neural networks responsible for neurocognition.
Authors & Co-authors:
Fountoulakis Konstantinos N KN
Dragioti Elena E
Theofilidis Antonis T AT
Wiklund Tobias T
Atmatzidis Xenofon X
Nimatoudis Ioannis I
Thys Erik E
Wampers Martien M
Hranov Luchezar L
Hristova Trayana T
Aptalidis Daniil D
Milev Roumen R
Iftene Felicia F
Spaniel Filip F
Knytl Pavel P
Furstova Petra P
From Tiina T
Karlsson Henry H
Walta Maija M
Salokangas Raimo K R RKR
Azorin Jean-Michel JM
Bouniard Justine J
Montant Julie J
Juckel Georg G
Haussleiter Ida S IS
Douzenis Athanasios A
Michopoulos Ioannis I
Ferentinos Panagiotis P
Smyrnis Nikolaos N
Mantonakis Leonidas L
Nemes Zsófia Z
Gonda Xenia X
Vajda Dora D
Juhasz Anita A
Shrivastava Amresh A
Waddington John J
Pompili Maurizio M
Comparelli Anna A
Corigliano Valentina V
Rancans Elmars E
Navickas Alvydas A
Hilbig Jan J
Bukelskis Laurynas L
Stevovic Lidija I LI
Vodopic Sanja S
Esan Oluyomi O
Oladele Oluremi O
Osunbote Christopher C
Rybakowski Janusz K JK
Wojciak Pawel P
Domowicz Klaudia K
Figueira Maria L ML
Linhares Ludgero L
Crawford Joana J
Panfil Anca-Livia AL
Smirnova Daria D
Izmailova Olga O
Lecic-Tosevski Dusica D
Temmingh Henk H
Howells Fleur F
Bobes Julio J
Garcia-Portilla Maria P MP
García-Alvarez Leticia L
Erzin Gamze G
Karadağ Hasan H
De Sousa Avinash A
Bendre Anuja A
Hoschl Cyril C
Bredicean Cristina C
Papava Ion I
Vukovic Olivera O
Pejuskovic Bojana B
Russell Vincent V
Athanasiadis Loukas L
Konsta Anastasia A
Stein Dan D
Berk Michael M
Dean Olivia O
Tandon Rajiv R
Kasper Siegfried S
De Hert Marc M
Study Outcome
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