Virtual Ontogeny of Cortical Growth Preceding Mental Illness.
Journal: Biological psychiatry
Volume: 92
Issue: 4
Year of Publication: 2022
Affiliated Institutions: Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. The Hospital for Sick Children and Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. Laboratory of Neuropsychiatry, Santa Lucia Foundation Scientific Institute for Research, Hospitalization and Healthcare, Rome, Italy. Departments of Education Science, Psychology, Communication Science, University of Bari Aldo Moro, Bari, Italy. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria del Hospital Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain; School of Medicine, Universidad Complutense, Madrid, Spain. Institute for Translational Psychiatry, University of Münster, Münster, Germany. National Centre for Scientific Research, Aix-Marseille University, Marseille, France. Department of Psychiatry, Marques de Valdecilla University Hospital, Instituto de Investigación Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain. Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Department of Genetics, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Department of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota. Department of Psychiatry, University of Vermont, Burlington, Vermont. Department of Clinical Radiology, University of Münster, Münster, Germany. Translational Developmental Neuroscience Section, Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Germany. Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy. Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Barcelona, Spain. Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zürich, Zurich, Switzerland. School of Psychiatry, Sydney, Australia. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany. Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico. Department of Developmental Neuroscience, Scientific Institute for Research, Hospitalization and Healthcare Stella Maris Foundation, Pisa, Italy. Institute of Neuroscience, Hospital Clinic, University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, CIBERSAM, Barcelona, Spain. FIDMAG Research Foundation, Barcelona, Spain. Clinical Neuroimaging Lab, Center for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway, Ireland. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. School of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada. Research Division, Institute of Mental Health, Singapore, Singapore. Department of Paediatrics, Department of Psychiatry, University of Melbourne, Parkville, Australia; Department of Psychiatry, Department of Psychiatry, University of Melbourne, Parkville, Australia. Department of Biomedical Sciences, Florida State University, Tallahassee, Florida. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Tübingen, Tübingen, Germany. Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway. Department of Psychiatry, Virgen del Rocio University Hospital, Universidad de Sevilla, Instituto de Biomedicina de Sevilla, CIBERSAM, Sevilla, Spain. Department of Psychology, University of Oslo, Oslo, Norway. Department of Psychiatry, Department of Psychiatry, University of Melbourne, Parkville, Australia. School of Medicine, Universidad Complutense, Madrid, Spain. Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. Laboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany. Department of Psychiatry, University of California San Diego, San Diego, California. Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Trinity Institute of Neuroscience, School of Medicine, Trinity College Dublin, Dublin, Ireland. San Francisco Veterans Affairs Medical Center, San Francisco, California. Neuroscience Research Australia, Sydney, Australia. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Parkville, Australia. Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland. Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California. Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, Maryland. Department of Psychology, Stanford University, Stanford, California. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. Department of Psychiatry, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Department of Psychiatry & Mental Health, Neuroscience Institute, University of Cape Town, Cape Town, South Africa. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University Hospital, Heidelberg, Germany. Department of Biomedicine, University of Bergen, Bergen, Norway. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, Australia. School of Medicine & Public Health, The University of Newcastle, Callaghan, New South Wales, Australia. Experimental and Clinical Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Norwegian Centre for Mental Disorders Research NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa. USC Mark and Mary Stevens Neuroimaging and Informatics Institute, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, California. Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands. Core Facility Brain imaging, Faculty of Medicine, University of Marburg, Marburg, Germany. Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. Mental Health Research Center, Moscow, Russia. Department of Psychiatry, Marburg University, Marburg, Germany. Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom. Departments of Psychiatry and Pediatrics, University of Calgary, Calgary, Alberta, Canada. Department for Data Capture and Collections Management, University Center for Information Technology, University of Oslo, Oslo, Norway. Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, California. Galway Neuroscience Centre, Center for Neuroimaging, Cognition and Genomics, Galway Neuroscience Centre, College of Medicine, Nursing, and Health Sciences, National University of Ireland Galway, Galway, Ireland. School of Psychology, College of Engineering, Science and Environment, The University of Newcastle, Callaghan, New South Wales, Australia. FIDMAG Germanes Hospitalàries Research Foundation, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. Department of Psychiatry and Psychotherapy, Philipps-Universität Marburg, Marburg, Germany. University Children's Hospital Zürich, Zurich, Switzerland. Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Carlton South, Victoria, Australia. Magnetic Resonance Imaging core facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. Department of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Würzburg, Germany. Graduate Program in Psychiatry and Behavioral Sciences, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Department of Psychiatry, Hospital Universitari Vall d'Hebrón, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain. Priority Centre for Brain & Mental Health Research, The University of Newcastle, Callaghan, New South Wales, Australia. Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt-Goethe University, Frankfurt am Main, Germany. National Institute for Nuclear Physics, Pisa Division, Pisa, Italy. Centre for Mental Health, School of Health Sciences, Swinburne University, Melbourne, Victoria, Australia. Department of Physiology and Biophysics, Instituto de Ciencias Biomédicas Universidade de São Paulo, São Paulo, Brazil. Child & Adolescent Psychiatry, King's College London, London, United Kingdom. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts. Johns Hopkins University School of Medicine, Baltimore, Maryland. Hunter Medical Research Institute, Newcastle, New South Wales, Australia. Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, Bari, Italy. School of Psychology, Deakin University, Geelong, Victoria, Australia. West Region, Institute of Mental Health, Singapore, Singapore. National Institute of Mental Health, Klecany, Czech Republic. Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. Imaging Genetics Center, USC Mark and Mary Stevens Neuroimaging & Informatics Institute, University of Southern California, Marina del Rey, California. Department of Radiology, University Hospital Marqués de Valdecilla, Instituto de Investigación Valdecilla, Santander, Spain. Laboratory of Medical Physics and Magnetic Resonance, Scientific Institute for Research, Hospitalization and Healthcare Stella Maris Foundation, Pisa, Italy. Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Germany. Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, Australia. Department of Radiology & Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. Department of Psychiatry, Autonomous University of Barcelona, Cerdanyola del Valles, Spain. Department of Neuroscience and Physiology, University of New South Wales, Sydney, Australia. SUNY Upstate Medical University, Syracuse, New York. Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital, University of Zürich, Zurich, Switzerland. German Center for Neurodegenerative Diseases, Site Rostock/Greifswald, Greifswald, Germany. Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, University of California San Francisco, San Francisco, California. NYU Grossman School of Medicine, New York, New York. Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands. Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands. Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia. Department of Psychiatry, Amsterdam UMC, VUMC, Amsterdam, The Netherlands. Georgia State University, Atlanta, Georgia. Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada; Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montréal, Montreal, Quebec, Canada. Electronic address: tpausresearch@gmail.com.
Abstract summary
Morphology of the human cerebral cortex differs across psychiatric disorders, with neurobiology and developmental origins mostly undetermined. Deviations in the tangential growth of the cerebral cortex during pre/perinatal periods may be reflected in individual variations in cortical surface area later in life.Interregional profiles of group differences in surface area between cases and controls were generated using T1-weighted magnetic resonance imaging from 27,359 individuals including those with attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depressive disorder, schizophrenia, and high general psychopathology (through the Child Behavior Checklist). Similarity of interregional profiles of group differences in surface area and prenatal cell-specific gene expression was assessed.Across the 11 cortical regions, group differences in cortical area for attention-deficit/hyperactivity disorder, schizophrenia, and Child Behavior Checklist were dominant in multimodal association cortices. The same interregional profiles were also associated with interregional profiles of (prenatal) gene expression specific to proliferative cells, namely radial glia and intermediate progenitor cells (greater expression, larger difference), as well as differentiated cells, namely excitatory neurons and endothelial and mural cells (greater expression, smaller difference). Finally, these cell types were implicated in known pre/perinatal risk factors for psychosis. Genes coexpressed with radial glia were enriched with genes implicated in congenital abnormalities, birth weight, hypoxia, and starvation. Genes coexpressed with endothelial and mural genes were enriched with genes associated with maternal hypertension and preterm birth.Our findings support a neurodevelopmental model of vulnerability to mental illness whereby prenatal risk factors acting through cell-specific processes lead to deviations from typical brain development during pregnancy.Authors & Co-authors: Patel Shin Abé Agartz Alloza Alnæs Ambrogi Antonucci Arango Arolt Auzias Ayesa-Arriola Banaj Banaschewski Bandeira Başgöze Cupertino Bau Bauer Baumeister Bernardoni Bertolino Bonnin Brandeis Brem Bruggemann Bülow Bustillo Calderoni Calvo Canales-Rodríguez Cannon Carmona Carr Catts Chenji Chew Coghill Connolly Conzelmann Craven Crespo-Facorro Cullen Dahl Dannlowski Davey Deruelle Díaz-Caneja Dohm Ehrlich Epstein Erwin-Grabner Eyler Fedor Fitzgerald Foran Ford Fortea Fuentes-Claramonte Fullerton Furlong Gallagher Gao Gao Goikolea Gotlib Goya-Maldonado Grabe Green Grevet Groenewold Grotegerd Gruber Haavik Hahn Harrison Heindel Henskens Heslenfeld Hilland Hoekstra Hohmann Holz Howells Ipser Jahanshad Jakobi Jansen Janssen Jonassen Kaiser Kaleda Karantonis King Kircher Kochunov Koopowitz Landén Landrø Lawrie Lebedeva Luna Lundervold MacMaster Maglanoc Mathalon McDonald McIntosh Meinert Michie Mitchell Moreno-Alcázar Mowry Muratori Nabulsi Nenadić O'Gorman Tuura Oosterlaan Overs Pantelis Parellada Pariente Pauli Pergola Piarulli Picon Piras Pomarol-Clotet Pretus Quidé Radua Ramos-Quiroga Rasser Reif Retico Roberts Rossell Rovaris Rubia Sacchet Salavert Salvador Sarró Sawa Schall Scott Selvaggi Silk Sim Skoch Spalletta Spaniel Stein Steinsträter Stolicyn Takayanagi Tamm Tavares Teumer Thiel Thomopoulos Tomecek Tomyshev Tordesillas-Gutiérrez Tosetti Uhlmann Van Rheenen Vazquez-Bourgón Vernooij Vieta Vilarroya Weickert Weickert Westlye Whalley Willinger Winter Wittfeld Yang Yoncheva Zijlmans Hoogman Franke van Rooij Buitelaar Ching Andreassen Pozzi Veltman Schmaal van Erp Turner Castellanos Pausova Thompson Paus
Study Outcome
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Citations :Authors : 196
Identifiers
Doi : 10.1016/j.biopsych.2022.02.959SSN : 1873-2402