Breakthrough SARS-CoV-2 infection and disease flares in patients with rheumatoid arthritis: result from COVAD e-survey study.

Journal: Rheumatology international

Volume: 44

Issue: 5

Year of Publication: 2024

Affiliated Institutions:  Rheumatologist at Complejo Asistencial Universitario de León, Castilla and Leon, Spain. Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. Centre for Rheumatic Diseases, King's College London, London, UK. Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung City, Taiwan. Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Cali, Colombia. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK. Southport and Ormskirk Hospital NHS Trust, Southport, PR PN, UK. Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, -- Sendagi, Bunkyo-ku, Tokyo, -, Japan. Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, , Australia. Mymensingh Medical College, Mymensingh, Bangladesh. Medical Faculty, Sofia University St. Kliment Ohridski, Kozyak Str., , Sofia, Bulgaria. Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre The University of Manchester, Manchester, UK. Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia. Maulana Azad Medical College, -Bahadurshah Zafar Marg, New Delhi, Delhi, , India. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. Department of Medical Research, Taichung Veterans General Hospital, Taichung City, Taiwan. ymchen@vghtc.gov.tw.

Abstract summary 

COVID-19 has been suggested as a possible trigger of disease flares in patients with rheumatoid arthritis (RA). However, factors associated with disease flares remain unknown. This study aimed to identify factors associated with breakthrough infection (BIs) and disease flares in patients with RA following COVID-19. We analysed data from RA patients who participated in the COVID-19 vaccination in autoimmune diseases (COVAD) study. Demographic data, patient-reported outcomes, comorbidities, pharmacologic treatment and details regarding disease flares were extracted from the COVAD database. Factors associated with disease flare-ups were determined by multivariate logistic regression analysis. The analysis comprised 1928 patients with RA who participated in the COVAD study. Younger age, Caucasian ethnicity, comorbidities with obstructive chronic pulmonary disease and asthma were associated with COVID-19 breakthrough infection. Moreover, younger age (odds ratio (OR): 0.98, 95% CI 0.96-0.99, p < 0.001), ethnicity other than Asian, past history of tuberculosis (OR: 3.80, 95% CI 1.12-12.94, p = 0.033), treatment with methotrexate (OR: 2.55, 95% CI: 1.56-4.17, p < 0.001), poor global physical health (OR: 1.07, 95% CI 1.00-1.15, p = 0.044) and mental health (OR: 0.91, 95% CI 0.87-0.95, p < 0.001) were independent factors associated disease flares in patients with RA. Our study highlights the impact of socio-demographic factors, clinical characteristics and mental health on disease flares in patients with RA. These insights may help determine relevant strategies to proactively manage RA patients at risk of flares.

Authors & Co-authors:  Santos Chen Nikiphorou Tseng Gutiérrez Tan Nune Kadam Kuwana Day Saha Velikova Lilleker Caballero-Uribe Sen Chinoy Aggarwal Agarwal Gupta Chen

Study Outcome 

Source Link: Visit source

Statistics
Citations :  Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, Tobin KA, Cerfolio RJ, Francois F, Horwitz LI (2022) Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ 369:m1966. https://doi.org/10.1136/bmj.m1966.PMID:32444366;PMCID:PMC7243801
Authors :  21
Identifiers
Doi : 10.1007/s00296-024-05542-3
SSN : 1437-160X
Study Population
Male,Female
Mesh Terms
Humans
Other Terms
Breakthrough infection;COVID-19;Disease flares;Rheumatoid arthritis
Study Design
Study Approach
Country of Study
Publication Country
Germany