Reducing the global burden of cerebral venous thrombosis: an international research agenda.
Journal: International journal of stroke : official journal of the International Stroke Society
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Affiliated Institutions:
Department of Neurology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
Stroke Center, Centro Hospitalar Universitário Lisboa Central, Institute of Anatomy, Faculdade de Medicina, Universidade de Lisboa, and L Lopes Lab, Instituto de Medicina Molecular JLA, Lisbon, Portugal.
Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany.
Christian Medical College Hospital, Vellore, India.
Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez, Mexico City, Mexico.
LIM-, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Helsinki University Hospital and University of Helsinki, Finland.
Department of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg,Sweden.
Brown University, Providence, Rhode Island, United States.
Centre for Clinical Transfusion Medicine, Medical Faculty of Tübingen, University of Tübingen.
Netherlands Thrombosis Foundation, Voorschoten, The Netherlands.
Department of Radiology and Nuclear Medicine, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.
Patients' representative, The Netherlands.
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Vancouver Stroke Program, Division of Neurology, University of British Columbia, Vancouver, Canada.
Inselspital Bern, University Hospital and University of Bern, Bern, Switzerland.
Hospital Germans Trias i Pujol, Badalona, Spain.
Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.
Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
North Lisbon University Hospital Center and Lisbon Medical School, Lisbon, Portugal.
Tel Aviv Sourasky Medical Center, Neurology, Tel Aviv, Israel.
Boston Medical Center, Boston, Massachusetts, United States.
Dutch Brain Foundation, The Hague, The Netherlands.
Stroke Outcomes & Decision Neuroscience Research Unit, University of Toronto, Toronto, Canada.
Royal Holloway University of London, London, United Kingdom.
Florey Institute of Neuroscience and Mental Health, Melbourne, Australia.
Dutch Heart Foundation, The Hague, the Netherlands.
UCL Queen Square Institute of Neurology, London, United Kingdom.
Portugal AVC- União de Sobreviventes, Familiares e Amigos, Portugal.
Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Department of Neurology, Sahlgrenska University Hospital and Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Hospital da Luz, University of Lisbon, Lisbon, Portugal.
Abstract summary
Due to the rarity of cerebral venous thrombosis (CVT), performing high-quality scientific research in this field is challenging. Providing answers to unresolved research questions will improve prevention, diagnosis, and treatment, and ultimately translate to a better outcome of patients with CVT. We present an international research agenda, in which the most important research questions in the field of CVT are prioritized.This research agenda has three distinct goals: (1) To provide inspiration and focus to research on CVT for the coming years; (2) To reinforce international collaboration; and (3) To facilitate the acquisition of research funding.This international research agenda is the result of a research summit organized by the International Cerebral Venous Thrombosis Consortium in Amsterdam, the Netherlands in June 2023. The summit brought together 45 participants from 15 countries including clinical researchers from various disciplines, patients who previously suffered from CVT, and delegates from industry and non-profit funding organizations. The research agenda is categorized into six pre-specified themes: (1) Epidemiology and clinical features; (2) Life after CVT; (3) Neuroimaging and diagnosis; (4) Pathophysiology; (5) Medical treatment; and (6) Endovascular Treatment. For each theme, we present two to four research questions, followed by a brief substantiation per question. The research questions were prioritized by the participants of the summit through consensus discussion.This international research agenda provides an overview of the most burning research questions on CVT. Answering these questions will advance our understanding and management of CVT, which will ultimately lead to improved outcomes for CVT patients worldwide.
Authors & Co-authors:
Coutinho
van de Munckhof
Aguiar de Sousa
Poli
Aaron
Arauz-Góngora
Conforto
Krzywicka
Hiltunen
Lindgren
Sanchez van Kammen
Shu
Bakchoul
Belder
van den Berg
Boumans
Cannegieter
Cano-Nigenda
Field
Fragata
Heldner
Hernández-Pérez
Klok
Leker
Lucas Neto
Molad
Nguyen
Saaltink
Saposnik
Sharma
Stam
Thijs
van der Vaart
Werring
Wong Ramos
Yaghi
Yesilot
Tatlisumak
Putaala
Jood
Arnold
Ferro
Study Outcome
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