Impaired health-related quality of life in idiopathic inflammatory myopathies: a cross-sectional analysis from the COVAD-2 e-survey.
Journal: Rheumatology advances in practice
Volume: 8
Issue: 2
Year of Publication:
Affiliated Institutions:
Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
Department of Biostatistics and Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
UKM Medical Centre, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Cheras, Malaysia.
Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
Maulana Azad Medical College, New Delhi, Delhi, India.
Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India.
Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India.
Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand.
Department of Rheumatology, Royal Melbourne Hospital, Parkville, VIC, Australia.
Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Division of Allergy, Immunology and Rheumatology, Department of Medical Research, Taichung Veterans General Hospital, Taiwan.
Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Accra, Ghana.
Medical Faculty, Sofia University St Kliment Ohridski, Sofia, Bulgaria.
Mymensingh Medical College, Mymensingh, Bangladesh.
Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Centre for Rheumatic Diseases, King's College London, London, UK.
NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
Southport and Ormskirk Hospital NHS Trust, Southport, UK.
Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia, Pavia, Lombardy, Italy.
Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Colombia.
Department of Medicine, Hospital Universidad del Norte, Barranquilla, Atlantico, Colombia.
Departamento de Reumatología Hospital de Especialidades Dr Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS, Mexico City, Mexico.
Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.
Rheumatology Department, Saint-Joseph University, Beirut, Lebanon.
Department of Rheumatology, Specialised Medical Center Hospital, Alfaisal University, Riyadh, Saudi Arabia.
Medizinische Klinik - Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Deutschland.
Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, University of Manchester, Manchester, UK.
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Abstract summary
To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database.Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores. Factors affecting GPH and GMH scores in IIMs were identified using multivariable regression analysis.We analysed responses from 1582 IIM, 4700 non-IIM AIRD and 545 nrAID patients and 3675 controls gathered through 23 May 2022. The median GPH scores were the lowest in IIM and non-IIM AIRD patients {13 [interquartile range (IQR) 10-15] IIMs 13 [11-15] non-IIM AIRDs 15 [13-17] nrAIDs 17 [15-18] controls, < 0.001}. The median GMH scores in IIM patients were also significantly lower compared with those without autoimmune diseases [13 (IQR 10-15) IIMs 15 (13-17) controls, < 0.001]. Inclusion body myositis, comorbidities, active disease and glucocorticoid use were the determinants of lower GPH scores, whereas overlap myositis, interstitial lung disease, depression, active disease, lower PROMIS Physical Function 10a and higher PROMIS Fatigue 4a scores were associated with lower GMH scores in IIM patients.Both physical and mental health are significantly impaired in IIM patients, particularly in those with comorbidities and increased fatigue, emphasizing the importance of patient-reported experiences and optimized multidisciplinary care to enhance well-being in people with IIMs.
Authors & Co-authors:
Yoshida
Li
Maroufy
Kuwana
Sazliyana Shaharir
Makol
Sen
Lilleker
Agarwal
Kadam
Akawatcharangura Goo
Day
Milchert
Chen
Dey
Velikova
Saha
Edgar Gracia-Ramos
Parodis
Nikiphorou
Tan
Nune
Cavagna
Toro Gutiérrez
Caballero-Uribe
Saavedra
Shinjo
Ziade
El Kibbi
Knitza
Distler
Chinoy
Agarwal
Aggarwal
Gupta
Study Outcome
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