Trait-dependent effects of theta burst stimulation after psychosocial stress: a sham-controlled study in healthy individuals.
Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
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Affiliated Institutions:
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium; Brain Stimulation and Cognition (BSC) Lab, Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, The Netherlands. Electronic address: stefaniedesmet.phd@gmail.com.
Tübingen Center for Mental Health (TüCMH), Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany.
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium; Department of Electronics and Information Systems, Ghent University, Belgium; Medical Imaging and Signal Processing (MEDISIP) Group, Ghent, Belgium.
Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Tübingen Center for Mental Health (TüCMH), Department of Psychiatry and Psychotherapy, University Hospital of Tuebingen, Tuebingen, Germany; German Center for Mental Health (DZPG), Germany.
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium; Department of Psychiatry, University Hospital (UZBrussel), Brussels, Belgium; Eindhoven University of Technology, Department of Electrical Engineering, Eindhoven, the Netherlands.
Department of Psychology, University of Tuebingen, Tuebingen, Germany.
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium; Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium.
Abstract summary
Previous studies suggest that theta burst stimulation (TBS), a form of repetitive transcranial magnetic stimulation (rTMS), applied to the left dorsolateral prefrontal cortex (DLPFC) might be a promising approach to modulate stress-reactive rumination and the associated psychophysiological stress response. Crucially, individuals showing higher levels of trait rumination might benefit more from prefrontal stimulation.In this sham-controlled study, 127 healthy individuals, with varying ruminative tendencies, received a single-session of intermittent TBS (iTBS), continuous TBS (cTBS) or sham TBS (sTBS) over the left DLPFC before being confronted with a Trier Social Stress Test.Results showed significant TBS effects on salivary cortisol as a function of trait rumination. cTBS, as compared to sTBS and iTBS, resulted in an attenuated stress-induced cortisol response in high compared to low trait ruminators. Although independent of trait rumination levels, cTBS showed positive effects on stress-related changes in mood and, both cTBS and iTBS (versus sham) presented an enhanced heart rate recovery following the stressor. We found no evidence for (trait rumination-dependent) TBS effects on stress-reactive rumination, negative affect, subjective stress or heart rate variability.cTBS shows beneficial effects on certain measures of stress, especially in high trait ruminators.These findings highlight the importance of accounting for individual differences when examining TBS effects.
Authors & Co-authors:
De Smet
Int-Veen
Vanhollebeke
Pulopulos
Barth
Pasche
Baeken
Nuerk
Plewnia
Nieratschker
Jochen Fallgatter
Ehlis
Vanderhasselt
Rosenbaum
Study Outcome
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